From North of Dubuque: Follow U.S. Highway 52 S through Dubuque, take ramp onto U.S. Highway 151 S/U.S. Highway 52 S./U.S. Highway 61 S. Continue following U.S. Highway 61 S. approx. 8 miles to Airport Road, turn right on Airport Road.
From East of Dubuque: Follow US-52 S/US-61 S. Continue to follow US-61 S. Turn right at Airport Rd, 1 mile to Airport Road
From South of Dubuque: Follow U.S. Highway 61 North to Airport Road. From Maquoketa approx. 25 miles, from Quad Cities, Moline, Rock Island, Bettendorf & Davenport approx. 65 miles.
From West of Dubuque: Follow U.S. Highway 20 East through Dubuque until U.S. Highway 61 South. Follow U.S. Highway 61 South approx. 8 miles to the Dubuque Regional Airport.